What Is Medication-Assisted Treatment (MAT) for Opioid Addiction and How Does It Work?

Samantha Rush, APRN, FNP-C

Medical Director of Residential & Withdrawal Services

Samantha Rush is a compassionate and committed healthcare professional with a strong dedication to serving individuals on their journey to wellness and recovery. As a Family Nurse Practitioner with advanced training and clinical expertise, Samantha brings more than a decade of experience in emergency medicine, behavioral health, and substance use treatment to her role as Medical Director of Residential & Withdrawal Services.   She began her academic journey at Neosho County Community College and Ottawa University, where she was honored with induction into Phi Theta Kappa for academic excellence. She earned her Master of Science in Nursing from Rockhurst University, becoming a board-certified Family Nurse Practitioner. Driven by a commitment to continuous growth and service, Samantha is currently pursuing additional certifications as a Psychiatric-Mental Health Nurse Practitioner and a master’s degree in medical Spanish.   Samantha has served in community mental health and detox programs for the past two years, where she has been recognized for her holistic, person-centered approach to care. Prior to this, she served as an emergency department charge nurse for ten years, bringing leadership and critical care expertise to fast-paced clinical environments. In 2024, Samantha was honored as one of the top five finalists for Best of Lawrence and has been nominated again for 2025, a reflection of her outstanding reputation and dedication to the community.   Outside of her professional life, Samantha is a proud wife and mother to five children and one stepson. She is actively involved in her family’s life as a dedicated cheer mom, baseball mom, and soccer mom—roles she embraces with the same passion and energy she brings to her clinical work.
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Addiction is not a character flaw. It’s not a sign of weakness, nor is it a moral failure. It’s a chronic medical condition—one that alters brain chemistry, hijacks decision-making, and makes recovery incredibly difficult without the right support. But recovery is possible. And today, we have more effective tools than ever to help individuals reclaim their health, stability, and lives.

One of the most powerful tools available is Medication-Assisted Treatment (MAT)—an evidence-based approach that combines FDA-approved medications with counseling and behavioral therapies. Unlike outdated, one-size-fits-all models of care, MAT is tailored to each person’s needs. It addresses both the physical grip of withdrawal and the emotional roots of addiction, offering a more holistic path to healing.

In this post, we’ll walk you through what MAT is, how it works in real-world treatment programs, and why it continues to transform outcomes for individuals with opioid use disorder.

If you’re curious about one of the most commonly used and accessible MAT options, read our post on buprenorphine treatment here.

What Is Medication-Assisted Treatment for Opioid Addiction(MAT)?

Medication-Assisted Treatment, or MAT, is a proven approach to treating substance use disorders—particularly opioid addiction—by combining FDA-approved medications with counseling and behavioral therapies. It’s not a shortcut. It’s a structured, whole-person treatment strategy that addresses both the physical and psychological aspects of addiction.

At its core, MAT is about stabilization and support. Medications reduce cravings and withdrawal. Therapy builds coping skills and addresses the root causes of addiction. Together, these components make it easier for people to stay in treatment, avoid relapse, and rebuild their lives.

One of the most common misunderstandings about MAT is that it’s simply “replacing one drug with another.” That myth is not only inaccurate—it’s dangerous. The medications used in MAT, like buprenorphine and methadone, don’t produce the same euphoric high as illicit opioids. Instead, they stabilize brain chemistry, giving people the clarity and consistency they need to fully engage in their recovery.

MAT doesn’t create dependence—it helps people break free from it.

How Medication-Assisted Treatment Works—and Why It Helps People Recover

When someone enters a treatment program that offers MAT, their journey begins with a thorough clinical assessment. This isn’t just about checking boxes—it’s about understanding the full picture: substance use history, mental and physical health, life circumstances, and goals for recovery. From there, a care team works with the individual to craft a personalized plan.

That plan often includes one of three FDA-approved medications: buprenorphine, methadone, or naltrexone. Each works differently, and the right choice depends on a variety of factors—prior use, co-occurring conditions, and even geography or insurance access. What they all share is a proven ability to reduce cravings, ease withdrawal, and protect against overdose.

But MAT doesn’t stop with medication. In fact, that’s just one part of the equation. True MAT integrates behavioral therapies, support groups, case management, and regular check-ins with providers. It’s delivered in different formats—clinic-based programs, office-based care, and increasingly, telehealth options that expand access for rural or underserved communities.

Perhaps most important, MAT is not one-size-fits-all. It’s highly individualized. Some people stay on medication for months. Others for years. The timeline is shaped by progress, not pressure. Healing moves at the pace of the person—not the expectations of others.

And the outcomes speak for themselves.

Studies consistently show that MAT improves survival rates, treatment retention, and employment outcomes. It reduces illicit drug use and criminal involvement. For many, it restores daily functioning, stabilizes families, and reignites hope. It makes long-term recovery not just a possibility—but a reality.

MAT isn’t about removing substances alone. It’s about restoring lives—physically, emotionally, and socially. It gives people a chance not just to survive, but to thrive.

Spotlight on Buprenorphine

Buprenorphine is one of the most common and accessible medications used in MAT. As a partial opioid agonist, it eases cravings and withdrawal without creating a full high. Its ceiling effect lowers the risk of overdose, making it a safer long-term option.

Unlike methadone, it can be prescribed in office settings—bringing treatment closer to home.

For a deeper dive, read our full post on buprenorphine treatment here.

MAT Access in Kansas

Access to Medication-Assisted Treatment is expanding across Kansas, thanks to key policy changes and growing public investment. The elimination of the federal X-waiver has made it easier for healthcare providers to prescribe medications like buprenorphine. At the same time, programs like the State Opioid Response (SOR) grant and the Kansas Fights Addiction Act are funding more treatment options statewide.

Still, rural areas face gaps in care—which makes local access more important than ever. At Avalon Wellness & Recovery in Lawrence, we’re proud to offer individualized, evidence-based MAT as part of our comprehensive approach to healing. Recovery shouldn’t depend on your ZIP code—and we’re here to help close the gap.

Common Questions About MAT

How long will I be on MAT?

There’s no one-size-fits-all answer. For some, MAT is short-term. For others, it’s part of long-term maintenance. What matters most is what supports your recovery—not a preset timeline.

Will I be able to work or parent while in treatment?

Yes. MAT is designed to help people stabilize, function, and thrive. Many individuals on MAT return to work, care for their families, and rebuild their lives.

Does insurance cover MAT?

Most insurance plans—including Medicaid—do cover MAT services. If you’re unsure, we can help you understand your options and advocate for the care you need.

At Avalon, we believe recovery should be accessible, respectful, and stigma-free. No shame. Just support.

Conclusion: A Path Forward

Medication-Assisted Treatment isn’t a shortcut—it’s a life-saving, research-backed approach to treating opioid addiction. By combining medication with compassionate therapy, MAT helps people reclaim stability, dignity, and hope.

At Avalon Wellness & Recovery, we’re here to walk that path with you. Whether you’re exploring treatment for yourself or a loved one, our team is ready to help with personalized support every step of the way.

If you or someone you love is ready to take the next step, our team in Lawrence is here to help. Call us today to learn more about starting MAT or beginning treatment at Avalon.

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